Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Ahmed Hjazi; Saade Abdalkareem Jasim; Farag M A Altalbawy; Harpreet Kaur; Hamza Fadhel Hamzah; Irwanjot Kaur; Mahamedha Deorari; Abhinav Kumar; Ahmed Elawady; Mohammed N Fenjan

doi:10.1007/s12013-024-01317-6

Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Cell Biochem Biophys. 2024 Sep;82(3):1613-1627. doi: 10.1007/s12013-024-01317-6. Epub 2024 May 28.

Authors

Ahmed Hjazi¹, Saade Abdalkareem Jasim², Farag M A Altalbawy³, Harpreet Kaur^{4

5}, Hamza Fadhel Hamzah⁶, Irwanjot Kaur^{7

8}, Mahamedha Deorari⁹, Abhinav Kumar¹⁰, Ahmed Elawady^{11

12

13}, Mohammed N Fenjan¹⁴

Affiliations

¹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
² Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. Saad.A.J.Anbar@gmail.com.
³ Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
⁴ School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
⁵ Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
⁶ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁷ Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bangalore, Karnataka, India.
⁸ Faculty of Health and Life Sciences, Management and Science University, Shah Alam, Malaysia.
⁹ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹⁰ Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, 620002, Russia.
¹¹ College of Technical Engineering, the Islamic University, Najaf, Iraq.
¹² College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹³ College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq.
¹⁴ College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.

PMID: 38806965
DOI: 10.1007/s12013-024-01317-6

Abstract

The advancement of novel technologies, coupled with bioinformatics, has led to the discovery of additional genes, such as long noncoding RNAs (lncRNAs), that are associated with drug resistance. LncRNAs are composed of over 200 nucleotides and do not possess any protein coding function. These lncRNAs exhibit lower conservation across species, are typically expressed at low levels, and often display high specificity towards specific tissues and developmental stages. The LncRNA MALAT1 plays crucial regulatory roles in various aspects of genome function, encompassing gene transcription, splicing, and epigenetics. Additionally, it is involved in biological processes related to the cell cycle, cell differentiation, development, and pluripotency. Recently, MALAT1 has emerged as a novel mechanism contributing to drug resistance or sensitivity, attracting significant attention in the field of cancer research. This review aims to explore the mechanisms through which MALAT1 confers resistance to chemotherapy and radiotherapy in cancer cells.

Keywords: Cancer; Chemo-radiotherapy; LncRNA; MALAT1; Resistance.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm* / genetics
Gene Expression Regulation, Neoplastic / drug effects
Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Neoplasms* / radiotherapy
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Radiation Tolerance / genetics

Substances

RNA, Long Noncoding
MALAT1 long non-coding RNA, human

Grants and funding

PSAU/2023/R/1445/Prince Sattam bin Abdulaziz University