A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Huina Guo; YiChen Lou; Xiaofang Hou; Qi Han; Yujia Guo; Zhongxun Li; Xiaoya Guan; Hongliang Liu; Chunming Zhang

doi:10.3389/fphar.2024.1415147

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Front Pharmacol. 2024 May 13:15:1415147. doi: 10.3389/fphar.2024.1415147. eCollection 2024.

Authors

Huina Guo^{1

2}, YiChen Lou^{1

2

3}, Xiaofang Hou^{1

2

3}, Qi Han^{1

2}, Yujia Guo^{1

2}, Zhongxun Li^{1

2}, Xiaoya Guan^{1

2}, Hongliang Liu^{1

2

4

5}, Chunming Zhang^{1

2

4}

Affiliations

¹ Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China.
² Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China.
³ The First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
⁴ Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.
⁵ Department of Cell Biology and Genetics, The Basic Medical School of Shanxi Medical University, Taiyuan, Shanxi, China.

Abstract

As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula's active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

Keywords: active ingredients; codonopsis pilosula (CP); combination drugs; cytoscape; diseases.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Basic Research Program of Shanxi Province (Free Exploration) (No. 202203021212036, 202203021211015, 202203021212032).