Development of a NiFe2O4 covalent organic framework based magnetic solid-phase extraction approach for specific capture of quinolones in animal innards prior to UHPLC-Q-Orbitrap HRMS detection

Shumin Lin; Yun-Kai Lv; Aixue Zhu; Ming Su; Xiliang Li; Shu-Xuan Liang

doi:10.1016/j.foodchem.2024.139796

Development of a NiFe₂O₄ covalent organic framework based magnetic solid-phase extraction approach for specific capture of quinolones in animal innards prior to UHPLC-Q-Orbitrap HRMS detection

Food Chem. 2024 Oct 1:454:139796. doi: 10.1016/j.foodchem.2024.139796. Epub 2024 May 22.

Authors

Shumin Lin¹, Yun-Kai Lv², Aixue Zhu³, Ming Su², Xiliang Li⁴, Shu-Xuan Liang⁵

Affiliations

¹ Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, PR China; Analysis and Testing Center, Inner Mongolia University of Science and Technology, Baotou 014010, PR China.
² Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, PR China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Baoding 071002, PR China.
³ Large Scale Instruments Shared Service Platform, Hebei University, Baoding 071002, PR China.
⁴ School of Public Health, Hebei University, Baoding 071002, China.
⁵ Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, PR China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Baoding 071002, PR China. Electronic address: liangsx168@126.com.

PMID: 38797102
DOI: 10.1016/j.foodchem.2024.139796

Abstract

This study aimed to present a selective and effective method for analyzing quinolones (QNs) in food matrix. Herein, a NiFe₂O₄-based magnetic sodium disulfonate covalent organic framework (NiFe₂O₄/COF) was prepared using a simple solvent-free grinding method, and was adopted as a selective adsorbent for magnetic solid phase extraction of QNs. Coupled with UHPLC-Q-Orbitrap HRMS, an efficient method for simultaneous detection of 18 kinds of QNs was established. The method exhibited good linearity (0.01-100 ng g^-1), high sensitivity (LODs ranging from 0.0011 to 0.0652 ng g^-1) and precision (RSDs below 9.5%). Successful extraction of QNs from liver and kidney samples was achieved with satisfactory recoveries ranging from 82.2% to 108.4%. The abundant sulfonate functional groups on NiFe₂O₄/COF facilitated strong affinity to QNs through electrostatic and hydrogen bonding interactions. The proposed method provides a new idea for the extraction of contaminants with target selectivity.

Keywords: Magnetic covalent organic frameworks; Magnetic solid-phase extraction; Quinolones; Response surface method; Solvent-free grinding method; Ultra-high performance liquid chromatography-high resolution mass spectrometry.

Publication types

Evaluation Study

MeSH terms

Adsorption
Animals
Chromatography, High Pressure Liquid
Ferric Compounds* / chemistry
Food Contamination* / analysis
Liver / chemistry
Mass Spectrometry
Metal-Organic Frameworks* / chemistry
Nickel / analysis
Nickel / chemistry
Nickel / isolation & purification
Quinolones* / analysis
Quinolones* / chemistry
Quinolones* / isolation & purification
Solid Phase Extraction* / instrumentation
Solid Phase Extraction* / methods

Substances

Quinolones
Metal-Organic Frameworks
Ferric Compounds
Nickel
nickel ferrite