A de novo TLR7 gain-of-function mutation causing severe monogenic lupus in an infant

Affiliations

• ¹ Translational and Clinical Research Institute, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
• ² Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
• ³ MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
• ⁴ Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
• ⁵ Department of Paediatrics and.
• ⁶ Exeter Genomics Laboratory, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.
• ⁷ Department of Paediatric Immunology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
• ⁸ Translational Health Sciences, University of Bristol, Bristol, United Kingdom.
• ⁹ Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.