The Regulation of Selenoproteins in Diabetes: A New Way to Treat Diabetes

Curr Pharm Des. 2024;30(20):1541-1547. doi: 10.2174/0113816128302667240422110226.

Abstract

Selenium is an essential micronutrient required for the synthesis and function of selenoproteins, most of which are enzymes involved in maintaining oxidative balance in the body. Diabetes is a group of metabolic disorders characterized by high blood glucose levels over a prolonged period of time. There are three main types of diabetes: type 1, type 2, and gestational diabetes. This review summarizes recent advances in the field of diabetes research with an emphasis on the roles of selenoproteins on metabolic disturbance in diabetes. We also discuss the interaction between selenoproteins and glucose and lipid metabolism to provide new insights into the prevention and treatment of diabetes.

Keywords: Glucose metabolism; diabetes; lipid metabolism; micronutrient.; selenium; selenoproteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / metabolism
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Selenium / metabolism
  • Selenoproteins* / metabolism

Substances

  • Selenoproteins
  • Hypoglycemic Agents
  • Selenium