Three cases of dogs with osteosarcoma of the forelimb treated with liquid nitrogen for limb-sparing surgery using autologous bone

J Vet Med Sci. 2024 Jun 19;86(6):700-707. doi: 10.1292/jvms.23-0390. Epub 2024 Apr 29.

Abstract

Osteosarcoma treatment with limb-sparing surgery using liquid nitrogen can be applied to canine patients experiencing diminished quality of life after leg amputation. In particular, forelimb amputation may affect gait more than hindlimb amputation. In this study, limb-sparing surgery using liquid nitrogen was applied to primary osteosarcomas arising in the proximal scapula of a Welsh Corgi, the proximal humerus of a Golden Retriever, and the distal radius of a Great Pyrenees, according to the protocol of Tsuchiya et al. In all cases, postoperative radiographic examination revealed bone union between the treated and matrix bones. All patients recovered their gait postoperatively. These results suggest that limb-sparing surgery using liquid nitrogen-treated autologous bone is an effective option for patients with osteosarcoma.

Keywords: autograft; forelimb; limb-sparing surgery; liquid nitrogen; osteosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Bone Neoplasms* / surgery
  • Bone Neoplasms* / veterinary
  • Bone Transplantation / methods
  • Bone Transplantation / veterinary
  • Dog Diseases* / surgery
  • Dogs
  • Female
  • Forelimb* / surgery
  • Humerus / surgery
  • Male
  • Nitrogen / therapeutic use
  • Osteosarcoma* / surgery
  • Osteosarcoma* / veterinary
  • Radius / surgery
  • Transplantation, Autologous / veterinary

Substances

  • Nitrogen