Radioprotective effect of Cerebrolysin in the Rat's Brain Tissues

Gholamreza Ghavipanjeh; Shahram Taeb; Mohammad Amin Farzin; Bagher Farhood; Masoud Najafi; Abolfazl Ardjmand

doi:10.2174/0125899775291111240409053824

Radioprotective effect of Cerebrolysin in the Rat's Brain Tissues

Curr Drug Res Rev. 2024 Apr 25. doi: 10.2174/0125899775291111240409053824. Online ahead of print.

Authors

Gholamreza Ghavipanjeh¹, Shahram Taeb², Mohammad Amin Farzin³, Bagher Farhood⁴, Masoud Najafi^{5

6}, Abolfazl Ardjmand¹

Affiliations

¹ Institute for Basic Sciences, Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
² Department of Radiology, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
³ Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
⁴ Department of Medical Physics and Radiology, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
⁵ Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁶ Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.

PMID: 38676482
DOI: 10.2174/0125899775291111240409053824

Abstract

Aim: The aim of this study is to evaluate radioprotective effects of Cerebrolysin (CBL) in rats' brain tissues after local irradiation.

Background: CBL has demonstrated antioxidant, anti-inflammatory, and tissue repair properties. In this study, the radioprotective effects of CBL in the brain tissues of rats after Irradiation (IR) (50 mg/ kg) were evaluated.

Objective: The levels of different oxidative stress markers, including malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were examined after treatment with radiation and CBL.

Methods: First, 20 male adult Wistar rats weighing 180-200 g were used. The animals were exposed to a single fraction of 15Gy using a linear accelerator unit at a dose rate of 200 cGy/mine. In this study, to check the amount of oxidative stress following the IR, the level of four markers MDA, NO, GPx, CAT, and SOD were examined and measured using the spectrophotometric method and purchased kits.

Results: The results showed that compared to the IR group, the administration of CBL increases the levels of GPX and SOD significantly (p < 0.05).

Conclusion: Our finding suggests that CBL has radioprotective effects on the brain by enhancing antioxidant defense mechanisms.

Keywords: Cerebrolysin; brain cancer; radioprotector; radiotherapy; stress oxidative..