The treatment of childhood acute lymphoblastic leukemia based on the pharmacokinetics of methotrexate in serum and cerebrospinal fluid

MeSH terms

• Antineoplastic Combined Chemotherapy Protocols / therapeutic use
• Blood-Brain Barrier
• Combined Modality Therapy
• Female
• Humans
• Kinetics
• Leukemia, Lymphoid / drug therapy*
• Leukemia, Lymphoid / metabolism
• Leukemia, Lymphoid / radiotherapy
• Male
• Methotrexate / blood
• Methotrexate / cerebrospinal fluid
• Methotrexate / metabolism*