Efficacy of CAR T-cell therapy is not impaired by previous bispecific antibody treatment in large B-cell lymphoma

Blood. 2024 Jul 18;144(3):334-338. doi: 10.1182/blood.2024024526.

Abstract

In this retrospective study, chimeric antigen receptor T cells remained effective in patients with relapsed/refractory large B-cell lymphoma after prior exposure to bispecific antibodies (BsAbs) targeting different antigens. These results are relevant to clinical practice, particularly given the increasing use of BsAbs in earlier treatment lines.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bispecific* / therapeutic use
  • Female
  • Humans
  • Immunotherapy, Adoptive* / methods
  • Lymphoma, Large B-Cell, Diffuse* / immunology
  • Lymphoma, Large B-Cell, Diffuse* / therapy
  • Male
  • Middle Aged
  • Receptors, Chimeric Antigen / immunology
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Antibodies, Bispecific
  • Receptors, Chimeric Antigen