Clear cell meningiomas-case presentation, review of radiographic identifiers, and treatment approaches

Childs Nerv Syst. 2024 Jul;40(7):1989-1996. doi: 10.1007/s00381-024-06390-z. Epub 2024 Apr 18.

Abstract

Spinal clear cell meningiomas (CCMs) are a rare histological subtype of meningiomas that pose preoperative diagnostic challenges due to their radiographic similarities with other lesions. They are also more aggressive, exhibiting higher rates of recurrence, particularly in pediatric patients. Overcoming diagnostic challenges of these tumors can improve patient outcomes. In this report, we describe a case of a pediatric patient presenting with a lumbar CCM in whom we were able to obtain gross total resection. Our report reviews previously identified predictors of CCM recurrence, including the Ki-67 proliferation index, number of spinal segments involved, and hormonal influences related to age and sex. We describe the characteristic radiographic features that differentiate spinal CCMs from other tumors to improve pre-operative diagnosis. Furthermore, we provide our rationale for adjuvant therapy for pediatric patients to refine treatment protocols for these rare tumors.

Keywords: Adjuvant therapy; Meningioma; Pediatric; Spine; Tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child
  • Humans
  • Magnetic Resonance Imaging
  • Meningeal Neoplasms* / diagnostic imaging
  • Meningeal Neoplasms* / pathology
  • Meningeal Neoplasms* / surgery
  • Meningioma* / diagnostic imaging
  • Meningioma* / surgery