Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study

Xiao Li Liu; Jinxin Zhao; Xue Min Di; Guohui Cao; Hongtao Zhang; Juan Wang

doi:10.3389/fonc.2024.1339955

Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study

Front Oncol. 2024 Apr 3:14:1339955. doi: 10.3389/fonc.2024.1339955. eCollection 2024.

Authors

Xiao Li Liu¹, Jinxin Zhao¹, Xue Min Di¹, Guohui Cao¹, Hongtao Zhang¹, Juan Wang¹

Affiliation

¹ Department of Oncology, Hebei General Hospital, Shijiazhuang, China.

Abstract

We report a case of recurrent retroperitoneal leiomyosarcoma in a male who achieved a rapid and robust but transient clinical response to low-dose iodine-125 brachytherapy. A FANCD2 frameshift mutation was detected by gene sequencing in the cancerous tissue.

Keywords: FANCD2; brachytherapy; low dose; radioactive iodine-125; retroperitoneal leiomyosarcoma.

Publication types

Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.