Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation

Wenyi Lu; Hairong Lyu; Xia Xiao; Xue Bai; Meng Zhang; Jiaxi Wang; Yedi Pu; Juanxia Meng; Xiaomei Zhang; Haibo Zhu; Ting Yuan; Bing Wang; Xin Jin; Xinping Cao; Zhao Wang; Tianle Xie; Haotian Meng; Alexey V Stepanov; Alexander G Gabibov; Yuxin An; Rui Sun; Yu Zhang; Mikhail A Maschan; Zunmin Zhu; Hongkai Zhang; Mingfeng Zhao

doi:10.1038/s41375-024-02251-5

Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation

Leukemia. 2024 Jun;38(6):1419-1422. doi: 10.1038/s41375-024-02251-5. Epub 2024 Apr 17.

Authors

Wenyi Lu^{1

2

3}, Hairong Lyu^{2

3}, Xia Xiao^{2

3}, Xue Bai^{2

3}, Meng Zhang^{2

3

4}, Jiaxi Wang^{2

3}, Yedi Pu^{2

3}, Juanxia Meng^{2

3}, Xiaomei Zhang^{2

3}, Haibo Zhu^{2

3}, Ting Yuan^{2

3}, Bing Wang^{2

3}, Xin Jin^{2

3}, Xinping Cao^{2

3}, Zhao Wang^{2

3}, Tianle Xie^{2

3}, Haotian Meng^{2

3}, Alexey V Stepanov⁵, Alexander G Gabibov⁵, Yuxin An^{2

3}, Rui Sun^{2

3}, Yu Zhang^{2

3}, Mikhail A Maschan⁶, Zunmin Zhu^#⁷, Hongkai Zhang^#⁸, Mingfeng Zhao^#^{9

10}

Affiliations

¹ Department of Hematology, Institute of Hematology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
² Department of Hematology, Tianjin First Central Hospital, Tianjin, China.
³ Department of Hematology, Nankai University Affiliated First Central Hospital, Tianjin, China.
⁴ Department of Hematology, Beijing Children's Hospital, Beijing, China.
⁵ M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
⁶ Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
⁷ Department of Hematology, Institute of Hematology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China. zhuzm1964@163.com.
⁸ State Key Laboratory of Medicinal Chemical Biology and College of Life Science, Nankai University, Tianjin, China. hongkai@nankai.edu.cn.
⁹ Department of Hematology, Tianjin First Central Hospital, Tianjin, China. mingfengzhao@sina.com.
¹⁰ Department of Hematology, Nankai University Affiliated First Central Hospital, Tianjin, China. mingfengzhao@sina.com.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Adolescent
Adult
Antigens, CD19* / immunology
Female
Hematopoietic Stem Cell Transplantation* / adverse effects
Hematopoietic Stem Cell Transplantation* / methods
Humans
Immunotherapy, Adoptive* / methods
Male
Middle Aged
Neoplasm Recurrence, Local / prevention & control
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy
Receptors, Chimeric Antigen / immunology
Recurrence
Tissue Donors*
Transplantation, Homologous*
Young Adult

Substances

Antigens, CD19
Receptors, Chimeric Antigen

Publication types

MeSH terms

Substances

Grants and funding