Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis

Sama Bitarafan; Feng Zhu; Ali Mirza; Charles N Bernstein; Gary Van Domselaar; Ruth Ann Marrie; E Ann Yeh; Yinshan Zhao; Brenda Banwell; Emmanuelle Waubant; Helen Tremlett

doi:10.1016/j.msard.2024.105599

Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis

Mult Scler Relat Disord. 2024 Jun:86:105599. doi: 10.1016/j.msard.2024.105599. Epub 2024 Apr 4.

Authors

Affiliations

¹ Faculty of Medicine (Neurology), University of British Columbia and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Faculty of Medicine (Neurology), University of British Columbia and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
³ Department of Internal Medicine and University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁴ National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁵ Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁶ Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, Division of Neuroscience and Mental Health, SickKids Research Institute, University of Toronto, Toronto, Canada.
⁷ Division of Child Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, USA.
⁸ Weill Institute for Neurosciences, Neurology Department, University of California, San Francisco, USA.
⁹ Faculty of Medicine (Neurology), University of British Columbia and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. Electronic address: helen.tremlett@ubc.ca.

PMID: 38604004
DOI: 10.1016/j.msard.2024.105599

Abstract

Objective: To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls.

Methods: The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression.

Results: The associations between diet and PoMS were modest, reaching significance for whole grain intake (adjusted odds ratio, aOR=0.964, 95 % confidence intervals, CI:0.934-0.995) but not mDII (aOR=1.20, 95 %CI:0.995-1.46) versus controls. No findings for monoADS reached significance versus controls.

Conclusions: Individuals with PoMS, but not monoADS, had lower dietary whole grain intake than controls.

Keywords: Case-control study; Dietary intake; Monophasic acquired demyelinating syndromes; Multiple sclerosis; Pediatric; Whole grain.

MeSH terms

Adolescent
Adult
Age of Onset
Child
Demyelinating Diseases
Diet / adverse effects
Diet / statistics & numerical data
Female
Humans
Inflammation
Male
Multiple Sclerosis*
Whole Grains
Young Adult