Immune signaling: receptor-like proteins make the difference

Wen R H Huang; Matthieu H A J Joosten

doi:10.1016/j.tplants.2024.03.012

Immune signaling: receptor-like proteins make the difference

Trends Plant Sci. 2024 Apr 8:S1360-1385(24)00068-2. doi: 10.1016/j.tplants.2024.03.012. Online ahead of print.

Authors

Wen R H Huang¹, Matthieu H A J Joosten²

Affiliations

¹ Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands.
² Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands. Electronic address: matthieu.joosten@wur.nl.

PMID: 38594153
DOI: 10.1016/j.tplants.2024.03.012

Abstract

To resist biotic attacks, plants have evolved a sophisticated, receptor-based immune system. Cell-surface immune receptors, which are either receptor-like kinases (RLKs) or receptor-like proteins (RLPs), form the front line of the plant defense machinery. RLPs lack a cytoplasmic kinase domain for downstream immune signaling, and leucine-rich repeat (LRR)-containing RLPs constitutively associate with the RLK SOBIR1. The RLP/SOBIR1 complex was proposed to be the bimolecular equivalent of genuine RLKs. However, it appears that the molecular mechanisms by which RLP/SOBIR1 complexes and RLKs mount immunity show some striking differences. Here, we summarize the differences between RLP/SOBIR1 and RLK signaling, focusing on the way these receptors recruit the BAK1 co-receptor and elaborating on the negative crosstalk taking place between the two signaling networks.

Keywords: SOBIR1; cell-surface immune receptors; crosstalk; immune signaling; leucine-rich repeat receptor-like kinases (RLKs); leucine-rich repeat receptor-like proteins (RLPs).

Publication types

Review