Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders

Abstract

Eosinophilic gastrointestinal disorder (EGID) is an umbrella term encompassing a group of chronic, immune-mediated disorders characterized by eosinophil-rich inflammation affecting one or more segments of the gastrointestinal tract. A recent consensus in nomenclature and emerging data made possible through multi-center consortia are beginning to unravel the molecular and cellular underpinnings of EGIDs below the esophagus. These emerging findings are revealing both overarching commonalities related to a food allergen-driven, chronic, Th2-mediated immune response as well as location-specific nuances in the pathophysiology of the collective EGIDs. Altogether, these advances offer promise for improved diagnoses and more efficacious interventional strategies.

Keywords: Eosinophilic colitis (EoC); Eosinophilic duodenitis (EoD); Eosinophilic enteritis (EoN); Eosinophilic gastritis (EoG); Eosinophilic gastroenteritis; Eosinophilic gastrointestinal disorder (EGID).