Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV

J Infect Dis. 2024 Aug 16;230(2):421-425. doi: 10.1093/infdis/jiae168.

Abstract

We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 kg and 0.98 kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.

Keywords: HIV; antiretroviral therapy; genetics; mitochondrial DNA; weight gain.

MeSH terms

  • Adult
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use
  • Body Mass Index*
  • DNA, Mitochondrial* / genetics
  • Female
  • HIV Infections* / drug therapy
  • HIV Infections* / genetics
  • Haplotypes*
  • Humans
  • Male
  • Middle Aged
  • Mitochondria / drug effects
  • Mitochondria / genetics
  • United Kingdom / epidemiology
  • Weight Gain* / drug effects
  • Weight Gain* / genetics

Substances

  • DNA, Mitochondrial
  • Anti-HIV Agents