Transannular Functionalization of Multiple C(sp3)-H Bonds of Tropane via an Alkene-Bridged Palladium(I) Dimer

Organometallics. 2023 Apr 24;42(8):627-631. doi: 10.1021/acs.organomet.3c00086. Epub 2023 Apr 10.

Abstract

This communication describes the Pd-catalyzed C(sp3)-H functionalization of a tropane derivative to generate products with functionalization at two (β/γ) or three (β/γ/β) different sites on the alicyclic amine core. These reactions proceed via an initial dehydrogenation to generate an alkene product that can react further to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer affords β/γ/β-functionalized allylic arylation and allylic acetoxylation products.