Strategies to promote implementation of core outcomes for medication adherence trials in rheumatology: A report from the OMERACT-Adherence Group

Aria Mohammadi Kordkheili; Charlotte Bekker; Alison M Hoens; Marieke Voshaar; Willemina Campbell; Loreto Carmona; Maarten de Wit; Lyn March; Sabrina Mai Nielsen; Beverley J Shea; Karine Toupin-April; Peter Tugwell; Kathleen Tymms; Ayano Kelly; Adherence Working Group

doi:10.1016/j.semarthrit.2024.152411

Strategies to promote implementation of core outcomes for medication adherence trials in rheumatology: A report from the OMERACT-Adherence Group

Semin Arthritis Rheum. 2024 Jun:66:152411. doi: 10.1016/j.semarthrit.2024.152411. Epub 2024 Feb 13.

Authors

Affiliations

¹ Faculty of Medicine & Health, School of Clinical Medicine, South West Sydney Campuses, University of New South Wales, Sydney, Australia.
² Radboud University Medical Center, Research Institute for Health Sciences, Department of Pharmacy, Nijmegen, the Netherlands.
³ Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada; OMERACT Patient Research Partner, Canada.
⁴ Department of Pharmacy and Department of Research & Innovation, Sint Maartenskliniek and Department of Pharmacy, Radboud University Medical Centre, Nijmegen, the Netherlands.
⁵ OMERACT Patient Research Partner, Canada.
⁶ Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain.
⁷ OMERACT Patient Research Partner, the Netherlands.
⁸ Department of Rheumatology, Royal North Shore Hospital, Sydney NSW, Australia.
⁹ Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
¹⁰ Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada.
¹¹ School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Children's Hospital of Eastern Ontario Research Institute; Institut du savoir Montfort.
¹² University of Ottawa, Department of Medicine, Faculty of Medicine, Ottawa, Canada; Bruyère Research Institute, Ottawa, Canada; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Canada; University of Ottawa, School of Epidemiology and Public Health, Faculty of Medicine, Ottawa, Canada; WHO Collaborating Centre for Knowledge Translation and Health Technology Assessment in Health Equity, Bruyère Research Institute, Ottawa, Canada.
¹³ Canberra Rheumatology, Canberra, ACT, Australia; Department of Rheumatology, Canberra Hospital, Canberra, Australia; College of Health and Medicine, Australian National University, Canberra, Australia.
¹⁴ Faculty of Medicine & Health, School of Clinical Medicine, South West Sydney Campuses, University of New South Wales, Sydney, Australia; Department of Rheumatology, Liverpool Hospital, Sydney, Australia; Ingham Institute of Applied Medical Research, Sydney Australia. Electronic address: ayano.kelly@unsw.edu.au.

PMID: 38537323
DOI: 10.1016/j.semarthrit.2024.152411

Abstract

Objectives: To identify barriers, facilitators, and strategies for future implementation of the OMERACT-Adherence Core Outcome Set (COS) in medication adherence trials for rheumatic conditions.

Methods: Preliminary Delphi survey findings were discussed at OMERACT 2023, utilising the Consolidated Framework for Implementation Research 2 to identify implementation barriers, facilitators, and solutions.

Results: Implementation strategies included simplifying the COS definitions, making it adaptabile for clinical practice and drug trials, adherence trial training workshops, and collaborating with key stakeholders such as payers and other COS developers.

Conclusion: Ongoing collaboration with individuals and organisations within and beyond rheumatology ensures broader applicability of OMERACT-Adherence COS.

Keywords: Implementation; Medication adherence; OMERACT.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antirheumatic Agents* / therapeutic use
Clinical Trials as Topic
Delphi Technique
Humans
Medication Adherence*
Outcome Assessment, Health Care
Rheumatic Diseases* / drug therapy
Rheumatology*

Substances

Antirheumatic Agents