Management of vaccinations in patients with non-Hodgkin lymphoma

Br J Haematol. 2024 May;204(5):1617-1634. doi: 10.1111/bjh.19422. Epub 2024 Mar 26.

Abstract

Vaccinations are fundamental tools in preventing infectious diseases, especially in immunocompromised patients like those affected by non-Hodgkin lymphomas (NHLs). The COVID-19 pandemic made clinicians increasingly aware of the importance of vaccinations in preventing potential life-threatening SARS-CoV-2-related complications in NHL patients. However, several studies have confirmed a significant reduction in vaccine-induced immune responses after anti-CD20 monoclonal antibody treatment, thus underscoring the need for refined immunization strategies in NHL patients. In this review, we summarize the existing data about COVID-19 and other vaccine's efficacy in patients with NHL and propose multidisciplinary team-based recommendations for the management of vaccines in this specific group of patients.

Keywords: COVID‐19; non‐Hodgkin lymphomas; rituximab; vaccines; zoster.

Publication types

  • Review

MeSH terms

  • COVID-19 / prevention & control
  • COVID-19 Vaccines* / adverse effects
  • COVID-19 Vaccines* / immunology
  • Humans
  • Immunocompromised Host
  • Lymphoma, Non-Hodgkin* / immunology
  • Lymphoma, Non-Hodgkin* / therapy
  • Vaccination*

Substances

  • COVID-19 Vaccines