Abstract
Maternal autoimmune disease is the most common cause of congenital heart block (CHB), a rare illness characterized by fibrosis and calcification of the fetal atrioventricular (AV) node due to maternal autoantibodies anti-SSA/Ro and anti-SSB/La. We report the full autopsy and clinical information on a female neonate with high degree AV block and calcification in the AV node, atrial approaches to the AV node, and both right and left bundle branches, born to a 27-year-old female with subclinical autoimmune disease.
Keywords:
AV node; Calcification; Heart block; Lupus.
Copyright © 2024 Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Antibodies, Antinuclear / blood
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Antibodies, Antinuclear / immunology
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Atrioventricular Block* / congenital
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Atrioventricular Block* / diagnosis
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Atrioventricular Block* / etiology
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Atrioventricular Block* / immunology
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Atrioventricular Block* / physiopathology
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Atrioventricular Node / pathology
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Atrioventricular Node / physiopathology
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Autoantibodies / blood
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Autoantibodies / immunology
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Autoimmune Diseases / complications
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Autoimmune Diseases / diagnosis
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Autoimmune Diseases / immunology
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Autoimmunity
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Autopsy
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Calcinosis / immunology
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Calcinosis / pathology
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Fatal Outcome
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Female
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Heart Block / congenital
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Humans
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Infant, Newborn
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Pregnancy
Substances
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Antibodies, Antinuclear
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Autoantibodies