A man with advanced HIV presented with verrucous plaques 2-3 months after initial mpox infection. He received two courses of tecovirimat without resolution of initial mpox lesions and development of new lesions raising concern for resistance. He was treated with two doses of brincidofovir and demonstrated improvement 6 months later.
Keywords: HIV/AIDS and other retroviruses; Mpox; brincidofovir; case report; cidofovir; disease outbreaks; sexually transmitted infections; tecovirimat; viruses.