IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging

Conor M Finlay; Judith E Allen

doi:10.1016/j.immuni.2024.02.013

IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging

Immunity. 2024 Mar 12;57(3):403-406. doi: 10.1016/j.immuni.2024.02.013.

Authors

Conor M Finlay¹, Judith E Allen²

Affiliations

¹ Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: cofinlay@tcd.ie.
² Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: judi.allen@manchester.ac.uk.

PMID: 38479355
DOI: 10.1016/j.immuni.2024.02.013

Abstract

Macrophages activated via the IL-4 receptor possess non-immune functions that support tissue homeostasis, but their specific role in aging is unknown. In this issue of Immunity, Zhou et al. show that IL-4 extends lifespan by inducing DNA repair pathways that protect macrophages from cellular senescence.

Publication types

Comment

MeSH terms

Cellular Senescence
Interleukin-4* / metabolism
Longevity
Macrophages*

Substances

Interleukin-4