Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro maturation within a single sample

Gretchen M Rosado; Ana Martinez-Marchal; Mariela Faykoo-Martinez; Melissa M Holmes; Miguel Angel Brieño-Enríquez

doi:10.1530/REP-23-0459

Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro maturation within a single sample

Reproduction. 2024 Apr 17;167(5):e230459. doi: 10.1530/REP-23-0459. Print 2024 May 1.

Authors

Gretchen M Rosado¹, Ana Martinez-Marchal¹, Mariela Faykoo-Martinez^{2

3

4}, Melissa M Holmes^{2

3}, Miguel Angel Brieño-Enríquez¹

Affiliations

¹ Magee-Womens Research Institute, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
² Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
³ Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
⁴ Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Abstract

Recently, we described that in the naked mole rat ovary it is possible to study the ovarian reserve and the mitotic expansion of the germ cell postnatally. Herein, we show oocyte in vitro maturation and in vitro germ cell expansion using the same ovary.

MeSH terms

Female
Germ Cells
Humans
In Vitro Oocyte Maturation Techniques
Oocytes
Ovarian Reserve*
Ovary*

Abstract

MeSH terms

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