Heated tobacco product IQOS induces unique metabolic signatures in human bronchial epithelial cells

Erin O Curley; Omran Abu Aboud; Kenneth J Chmiel; Ajay P Nayak; Oliver Fiehn; Amir A Zeki; Pawan Sharma

doi:10.1183/23120541.00805-2023

Heated tobacco product IQOS induces unique metabolic signatures in human bronchial epithelial cells

ERJ Open Res. 2024 Mar 4;10(2):00805-2023. doi: 10.1183/23120541.00805-2023. eCollection 2024 Mar.

Authors

Erin O Curley¹, Omran Abu Aboud², Kenneth J Chmiel², Ajay P Nayak¹, Oliver Fiehn³, Amir A Zeki^{2

4

5

6}, Pawan Sharma^{1

6}

Affiliations

¹ Center for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane and Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
² UC Davis Lung Center, Davis, CA, USA.
³ West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, CA, USA.
⁴ UC Davis Reversible Obstructive Airway Disease Center, Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, Davis, CA, USA.
⁵ Veterans Affairs Medical Center, Sacramento, CA, USA.
⁶ A.A. Zeki and P. Sharma contributed equally to this article as lead authors and supervised the work.

Abstract

Metabolic signatures are lacking for heated tobacco products, making it crucial to identify new biosignatures of lung damage. This will enable the establishment of product-specific guidelines and an understanding of associated toxicity. https://bit.ly/3TkhBox.

Abstract

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