Osteonecrosis of sternum and rib in a patient treated for Hodgkin's disease

Cancer. 1985 Nov 1;56(9):2292-4. doi: 10.1002/1097-0142(19851101)56:9<2292::aid-cncr2820560925>3.0.co;2-8.

Abstract

A 39-year-old man is described in whom osteonecrosis of the manubrium sterni developed 23 months and of a rib 25 months after treatment for Hodgkin's disease Stage IIIB with polychemotherapy and subdiaphragmatic radiotherapy. The radiologic and histologic characteristics of this very rare localization of steroid-associated osteonecrosis are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Combined Modality Therapy
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / radiotherapy
  • Humans
  • Male
  • Mechlorethamine / administration & dosage
  • Mechlorethamine / adverse effects
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / pathology
  • Prednisone / administration & dosage
  • Prednisone / adverse effects
  • Procarbazine / administration & dosage
  • Procarbazine / adverse effects
  • Ribs / pathology*
  • Sternum / pathology*
  • Vincristine / administration & dosage
  • Vincristine / adverse effects

Substances

  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Prednisone

Supplementary concepts

  • MOPP protocol