Non-tuberculous mycobacterial pulmonary disease (NTM-PD): Epidemiology, diagnosis and multidisciplinary management

Kartik Kumar; Aravind Ponnuswamy; Toby Gd Capstick; Christabelle Chen; Douglas McCabe; Rhys Hurst; Lisa Morrison; Fiona Moore; Matt Gallardo; Jennie Keane; Shirley Harwood; Tanya Sinnett; Sarah Bryant; Ronan Breen; Onn Min Kon; Marc Lipman; Michael R Loebinger; Devesh J Dhasmana

doi:10.1016/j.clinme.2024.100017

Non-tuberculous mycobacterial pulmonary disease (NTM-PD): Epidemiology, diagnosis and multidisciplinary management

Clin Med (Lond). 2024 Jan;24(1):100017. doi: 10.1016/j.clinme.2024.100017. Epub 2024 Jan 17.

Authors

Kartik Kumar¹, Aravind Ponnuswamy², Toby Gd Capstick³, Christabelle Chen⁴, Douglas McCabe⁵, Rhys Hurst⁶, Lisa Morrison⁷, Fiona Moore⁷, Matt Gallardo⁸, Jennie Keane⁹, Shirley Harwood¹⁰, Tanya Sinnett¹⁰, Sarah Bryant¹¹, Ronan Breen¹², Onn Min Kon¹³, Marc Lipman¹⁴, Michael R Loebinger¹⁵, Devesh J Dhasmana¹⁶

Affiliations

¹ Host Defence Unit, Department of Respiratory Medicine, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: https://twitter.com/DrKartikKumar.
² Department of Respiratory Medicine, Royal Liverpool University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; Chester Medical School, University of Chester, Chester, UK.
³ Pharmacy Department, St James's University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address: https://twitter.com/tcapper78.
⁴ Pharmacy Department, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK. Electronic address: https://twitter.com/Christab3lleMin.
⁵ Pharmacy Department, Western General Hospital, NHS Lothian, Edinburgh, UK.
⁶ Department of Thoracic Medicine, Royal Papworth Hospital, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK. Electronic address: https://twitter.com/RespPT_rhys.
⁷ West of Scotland Adult Cystic Fibrosis Unit, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
⁸ Tuberculosis Service, Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
⁹ Tuberculosis Service, Raphael House, Essex Partnership University NHS Foundation Trust, Rochford, UK.
¹⁰ NTM Patient Care UK.
¹¹ NTM Network UK, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK.
¹² Department of Respiratory Medicine, Forth Valley Royal Hospital, NHS Forth Valley, Larbert, UK.
¹³ National Heart and Lung Institute, Imperial College London, London, UK; Department of Respiratory Medicine, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK. Electronic address: https://twitter.com/onnmin.
¹⁴ Department of Respiratory Medicine, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK; UCL Respiratory, Division of Medicine, University College London, London, UK.
¹⁵ Host Defence Unit, Department of Respiratory Medicine, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: https://twitter.com/mloebinger.
¹⁶ Department of Respiratory Medicine, Victoria Hospital, NHS Fife, Kirkcaldy, UK; School of Medicine, North Haugh, University of St Andrews, St Andrews, UK. Electronic address: djd5@st-andrews.ac.uk.

Abstract

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause significant disease in both immunocompromised and immunocompetent individuals. The incidence of NTM pulmonary disease (NTM-PD) is rising globally. Diagnostic challenges persist and treatment efficacy is variable. This article provides an overview of NTM-PD for clinicians. We discuss how common it is, who is at risk, how it is diagnosed and the multidisciplinary approach to its clinical management.

Keywords: Diagnosis; Epidemiology; Multidisciplinary management; Non-tuberculous mycobacteria; Pulmonary disease.

Publication types

Review

MeSH terms

Humans
Immunocompromised Host*
Nontuberculous Mycobacteria*