Diagnostic and management strategies in cardiac sarcoidosis

Int J Cardiol. 2024 May 15:403:131853. doi: 10.1016/j.ijcard.2024.131853. Epub 2024 Feb 17.

Abstract

Cardiac sarcoidosis (CS) is increasingly recognized in the context of with otherwise unexplained electrical or structural heart disease due to improved diagnostic tools and awareness. Therefore, clinicians require improved understanding of this rare but fatal disease to care for these patients. The cardinal features of CS, include arrhythmias, atrio-ventricular conduction delay and cardiomyopathy. In addition to treatments tailored to these cardiac manifestations, immunosuppression plays a key role in active CS management. However, clinical trial and consensus guidelines are limited to guide the use of immunosuppression in these patients. This review aims to provide a practical overview to the current diagnostic challenges, treatment approach, and future opportunities in the field of CS.

Keywords: Arrhythmias; Cardiac sarcoidosis; Cardiomyopathy; Heart failure; Immunosuppression.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac
  • Cardiomyopathies* / diagnosis
  • Cardiomyopathies* / therapy
  • Heart
  • Heart Diseases*
  • Humans
  • Myocarditis*
  • Sarcoidosis* / diagnosis
  • Sarcoidosis* / epidemiology
  • Sarcoidosis* / therapy