Cytotoxic ent- abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis

Yanisa Olaranont; Eduard Mas-Claret; Martin Cheek; Thomas A K Prescott; Jean Michel Onana; Moses K Langat

doi:10.1016/j.heliyon.2024.e25917

Cytotoxic ent- abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis

Heliyon. 2024 Feb 8;10(3):e25917. doi: 10.1016/j.heliyon.2024.e25917. eCollection 2024 Feb 15.

Authors

Yanisa Olaranont^{1

2}, Eduard Mas-Claret¹, Martin Cheek¹, Thomas A K Prescott¹, Jean Michel Onana^{3

4}, Moses K Langat¹

Affiliations

¹ Royal Botanic Gardens Kew, Richmond, TW9 3AE, Surrey, UK.
² Department of Plant Science, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
³ Department of Plant Biology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
⁴ IRAD-National Herbarium of Cameroon, Yaoundé, PO Box 1601, Cameroon.

Abstract

The chemical investigation of a leaf extract from a herbarium specimen of Suregada occidentalis collected in Banyang Mbo Wildlife Sanctuary, Southwest Region, Cameroon, yielded five undescribed ent-abietane diterpenoids, banyangmbolides A-E, (1-5), and four known diterpenoids, gelomulides A (6), B (7), D (8) and O (9). The structures of the isolated compounds were determined using NMR, IR, ECD and HRESIMS. Compounds 5, 7 and 8, showed 48-55% inhibition at 200 μM against FM-55-M1 human melanoma cells.

Keywords: Banyangmbolides; Cytotoxicity; Ent-abietane; Euphorbiaceae; Gelumolides; Suregada occidentalis.