Coulomb crystals provide a unique environment in which to study ion-neutral gas-phase reactions. In these cold, trapped ensembles, we are able to study the kinetics and dynamics of small molecular systems. These measurements have connections to chemistry in the Interstellar Medium (ISM) and planetary atmospheres. This Feature Article will describe recent work in our laboratory that uses Coulomb crystals to study translationally cold, ion-neutral reactions. We provide a description of how the various affordances of our experimental system allow for detailed studies of the reaction mechanisms and the corresponding products. In particular, we will describe quantum-state resolved reactions, isomer-dependent reactions, and reactions with a rarely studied, astrophysically relevant ion, CCl+.