Advances in inhibitor development targeting the PWWP domain

Yunyuan Huang; Yanxi Li; Jinrong Min

doi:10.1016/j.tips.2024.01.007

Advances in inhibitor development targeting the PWWP domain

Trends Pharmacol Sci. 2024 Mar;45(3):193-196. doi: 10.1016/j.tips.2024.01.007. Epub 2024 Feb 9.

Authors

Yunyuan Huang¹, Yanxi Li¹, Jinrong Min²

Affiliations

¹ Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
² Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China. Electronic address: minjinrong@ccnu.edu.cn.

PMID: 38341359
DOI: 10.1016/j.tips.2024.01.007

Abstract

The PWWP domain binds to both histone and DNA of a nucleosome in a bivalent way. PWWP domain-containing proteins are involved in different biological processes, and their aberrant expression is implicated in various human diseases. Here, we discuss the recent developments and challenges in targeting the PWWP domain for therapeutic intervention.

Keywords: PROTAC; PWWP domain; aromatic cage; nucleosome-binding.

MeSH terms

DNA* / metabolism
Histones* / metabolism
Humans
Protein Binding
Protein Domains

Substances

Histones
DNA