Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group

Naoki Asayama; Shiro Oka; Shinji Nagata; Taiji Matsuo; Taiki Aoyama; Toru Kawamura; Tsuyoshi Kuroda; Yuko Hiraga; Koichi Nakadoi; Masaki Kunihiro; Mayu Ohnishi; Shinji Tanaka

doi:10.23922/jarc.2023-030

Adherence and Effectiveness of MoviPrep^Ⓡ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group

J Anus Rectum Colon. 2024 Jan 25;8(1):9-17. doi: 10.23922/jarc.2023-030. eCollection 2024.

Authors

Affiliations

¹ Department of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
² Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
³ Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
⁴ Kawamura Clinic, Hiroshima, Japan.
⁵ Department of Gastroenterology, Mazda Hospital, Hiroshima, Japan.
⁶ Department of Endoscopy, Hiroshima Prefectural Hospital, Hiroshima, Japan.
⁷ Department of Gastroenterology, Onomichi General Hospital, Onomichi, Japan.
⁸ Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
⁹ Department of Gastroenterology, Miyoshi Medical Association Hospital, Hiroshima, Japan.

Abstract

Objectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution Niflec^Ⓡ (Nif). MoviPrep (Mov)^Ⓡ is a hyperosmolar preparation of PEG, electrolytes, and ascorbic acid; despite the smaller dose volume of 2 L, it can be challenging for many patients. We examined a more effective and acceptable bowel preparation method without compromising cleanliness and effectiveness, combining low-residue diet and laxative (Modified Brown Method) in Mov administered 1 day pre-colonoscopy.

Methods: This multicenter, randomized, open-label, parallel-group comparative study, conducted at Hiroshima University Hospital and 7 affiliated hospitals in May 2015-March 2016, evaluated adherence to and effectiveness of Mov in bowel preparation. Participants (n=380) were allocated to receive 1 of 3 pre-colonoscopy regimens: Nif+Modified Brown Method (Group A), Mov+Modified Brown Method (Group B), or Mov+Laxative (Group C).

Results: Total intake volume showed no significant difference among the groups. Bowel preparation time was significantly shorter in Group B (112.4±44.8 min, n=118) than in Groups A (131.3±59 min, n=105) and C (122.6±48.1 min, n=115). Sleep disturbance (37%) was significantly higher in Group B than Group A; distension (11%) was significantly lower in Group C than in Groups A and B (p<0.05, respectively). No severe adverse events occurred in any group.

Conclusions: Mov+Modified Brown method provided significantly shorter bowel preparation time, with no significant difference in total intake volume among the regimens. Mov+Laxative yielded significantly less distension than the other groups, with bowel preparation equivalent to that of the Nif+Modified Brown method.

Keywords: Modified Brown Method; MoviPrepⓇ; bowel preparation; colonoscopy.