A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis

Raed Obaid Saleh; Sulieman Ibraheem Shelash Al-Hawary; Saade Abdalkareem Jasim; Dmitry Olegovich Bokov; Ahmed Hjazi; Khulood H Oudaha; Mohammed Jawad Alnajar; Sally Salih Jumaa; Ahmed Alawadi; Ali Alsalamy

doi:10.1007/s12032-023-02275-4

A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis

Med Oncol. 2024 Feb 4;41(3):69. doi: 10.1007/s12032-023-02275-4.

Authors

Affiliations

¹ Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
² Department of Business Administration, School of Business, Al-albayt University, P.O.BOX 130040, Mafraq, 25113, Jordan.
³ Biotechnology Department, College of Applied Science, Fallujah University, Anbar, Iraq. saadeek.jasim@uofallujah.edu.iq.
⁴ Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., Bldg. 2, Moscow, 119991, Russian Federation.
⁵ Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky Pr, Moscow, 109240, Russian Federation.
⁶ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
⁷ Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.
⁸ Anesthesia Techniques, Al-Nisour University College, Baghdad, Iraq.
⁹ College of Pharmacy/National University of Science and Technology, Dhi Qar, Iraq.
¹⁰ College of Technical Engineering, The Islamic University, Najaf, Iraq.
¹¹ College of Technical Engineering, The Islamic University of Al Diwaniyah,, Al Diwaniyah, Iraq.
¹² College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq.
¹³ College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq.

PMID: 38311682
DOI: 10.1007/s12032-023-02275-4

Abstract

Pre-messenger RNA molecules are back-spliced to create circular RNAs, which are non-coding RNA molecules. After a thorough investigation, it was discovered that these circRNAs have critical biological roles. CircRNAs have a variety of biological functions, including their ability to operate as microRNA sponges, interact with proteins to alter their stabilities and activities, and provide templates for the translation of proteins. Evidence supports a link between the emergence of numerous diseases, including various cancer types, and dysregulated circRNA expression. It is commonly known that a significant contributing element to cancer development is the disruption of numerous molecular pathways essential for preserving cellular and tissue homeostasis. The dysregulation of multiple biological processes is one of the hallmarks of cancer, and the molecular pathways linked to these processes are thought to be promising targets for therapeutic intervention. The biological and carcinogenic effects of circRNAs in the context of cancer are thoroughly reviewed in this article. Specifically, we highlight circRNAs' involvement in signal transduction pathways and their possible use as novel biomarkers for the early identification and prognosis of human cancer.

Keywords: Cancer; Circ-RNAs; Non-coding RNAs; Signaling pathways.

Publication types

Review

MeSH terms

Humans
MicroRNAs*
Neoplasms* / genetics
Neoplasms* / pathology
RNA, Circular / genetics
RNA, Messenger
Signal Transduction / genetics

Substances

RNA, Circular
MicroRNAs
RNA, Messenger