Developing and describing a typology of lucid episodes among people with Alzheimer's disease and related dementias

Alzheimers Dement. 2024 Apr;20(4):2434-2443. doi: 10.1002/alz.13667. Epub 2024 Feb 2.

Abstract

Introduction: This study examined lucid episodes among people living with late-stage Alzheimer's disease and related dementias (PLWD) and then developed a typology of these episodes to help characterize them.

Methods: Family caregivers of PLWD provided information about witnessed episodes, including proximity to death, cognitive status, duration, communication quality, and circumstances prior to lucid episodes on up to two episodes (caregiver N = 151; episode N = 279). Latent class analysis was used to classify and characterize empirically distinct clusters of lucid episodes.

Results: Four lucid episode types were identified. The most common type occurred during visits with family and among PLWD who lived > 6 months after the episode. The least common type coincided with family visits and occurred within 7 days of the PLWD's death.

Discussion: Findings suggest that multiple types of lucid episodes exist; not all signal impending death; and some, but not all, are precipitated by external stimuli.

Keywords: Alzheimer's disease and related dementias; family caregivers; lucidity; paradoxical lucidity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / psychology
  • Caregivers
  • Cognition
  • Communication
  • Humans