Clinical Outcomes of US Adults Hospitalized for COVID-19 and Influenza in the Respiratory Virus Hospitalization Surveillance Network, October 2021-September 2022

Noah Kojima; Christopher A Taylor; Mark W Tenforde; Dawud Ujamaa; Alissa O'Halloran; Kadam Patel; Shua J Chai; Pam Daily Kirley; Nisha B Alden; Breanna Kawasaki; James Meek; Kimberly Yousey-Hindes; Evan J Anderson; Kyle P Openo; Libby Reeg; Val Tellez Nunez; Ruth Lynfield; Kathryn Como-Sabetti; Susan L Ropp; Yomei P Shaw; Nancy L Spina; Grant Barney; Sophrena Bushey; Kevin Popham; Nancy E Moran; Eli Shiltz; Melissa Sutton; Nasreen Abdullah; H Keipp Talbot; William Schaffner; Ryan Chatelain; Andrea Price; Shikha Garg; Fiona P Havers; Catherine H Bozio

doi:10.1093/ofid/ofad702

Clinical Outcomes of US Adults Hospitalized for COVID-19 and Influenza in the Respiratory Virus Hospitalization Surveillance Network, October 2021-September 2022

Open Forum Infect Dis. 2023 Dec 30;11(1):ofad702. doi: 10.1093/ofid/ofad702. eCollection 2024 Jan.

Authors

Noah Kojima^{1

2}, Christopher A Taylor³, Mark W Tenforde¹, Dawud Ujamaa¹, Alissa O'Halloran¹, Kadam Patel³, Shua J Chai^{4

5}, Pam Daily Kirley⁵, Nisha B Alden⁶, Breanna Kawasaki⁶, James Meek^{7

8}, Kimberly Yousey-Hindes⁷, Evan J Anderson^{9

10

11}, Kyle P Openo^{9

10

11}, Libby Reeg¹², Val Tellez Nunez¹², Ruth Lynfield¹³, Kathryn Como-Sabetti¹³, Susan L Ropp¹⁴, Yomei P Shaw¹⁴, Nancy L Spina¹⁵, Grant Barney¹⁵, Sophrena Bushey¹⁶, Kevin Popham¹⁶, Nancy E Moran¹⁷, Eli Shiltz¹⁷, Melissa Sutton¹⁸, Nasreen Abdullah¹⁸, H Keipp Talbot¹⁹, William Schaffner¹⁹, Ryan Chatelain²⁰, Andrea Price²⁰, Shikha Garg¹, Fiona P Havers³, Catherine H Bozio¹

Affiliations

¹ Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
³ Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁴ California Emerging Infections Program, Oakland, California, USA.
⁵ Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁶ Colorado Department of Public Health and Environment, Denver, Colorado, USA.
⁷ Connecticut Emerging Infections Program, New Haven, Connecticut, USA.
⁸ Yale School of Public Health, New Haven, Connecticut, USA.
⁹ School of Medicine, Emory University, Atlanta, Georgia, USA.
¹⁰ Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta, Georgia, USA.
¹¹ Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.
¹² Michigan Department of Health and Human Services, Lansing, Michigan, USA.
¹³ Minnesota Department of Health, Saint Paul, Minnesota, USA.
¹⁴ New Mexico Department of Health, Albuquerque, New Mexico, USA.
¹⁵ New York State Department of Health, Albany, New York, USA.
¹⁶ School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
¹⁷ Ohio Department of Health, Columbus, Ohio, USA.
¹⁸ Public Health Division, Oregon Health Authority, Portland, Oregon, USA.
¹⁹ Vanderbilt University Medical Center, Nashville, Tennessee, USA.
²⁰ Salt Lake County Health Department, Salt Lake City, Utah, USA.

Abstract

Severe outcomes were common among adults hospitalized for COVID-19 or influenza, while the percentage of COVID-19 hospitalizations involving critical care decreased from October 2021 to September 2022. During the Omicron BA.5 period, intensive care unit admission frequency was similar for COVID-19 and influenza, although patients with COVID-19 had a higher frequency of in-hospital death.

Keywords: COVID-19; SARS-CoV-2; hospital outcomes; influenza; severe disease.