An unusual form of BRAF-V600E mutated hairy cell neoplasm with clinical resistance to BRAF inhibition: Challenging precision medicine

Andrea Marra; Alessia Santi; Alessandra Pucciarini; Alessandra Venanzi; Luca De Carolis; Francesco Zaja; Stefano Ascani; Vincenzo Canzonieri; Stelvio Ballanti; Brunangelo Falini; Enrico Tiacci

doi:10.1002/ajh.27201

An unusual form of BRAF-V600E mutated hairy cell neoplasm with clinical resistance to BRAF inhibition: Challenging precision medicine

Am J Hematol. 2024 Mar;99(3):497-501. doi: 10.1002/ajh.27201. Epub 2024 Jan 24.

Authors

Affiliations

¹ Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
² Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, Rome, Italy.
³ Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome, Italy.
⁴ Hematology Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
⁵ Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
⁶ Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, Terni, Italy.
⁷ Division of Pathology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), National Cancer Institute, Aviano, Italy.

PMID: 38264797
DOI: 10.1002/ajh.27201

Abstract

Distinct outcomes of BRAF inhibition in BRAF-mutated hairy cell neoplasms with wild-type or mutant TP53, and alternative strategies to overcome mutant TP53.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mutation
Neoplasms*
Precision Medicine
Proto-Oncogene Proteins B-raf* / genetics

Substances

Proto-Oncogene Proteins B-raf
BRAF protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding