Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution

Front Integr Neurosci. 2024 Jan 8:17:1299087. doi: 10.3389/fnint.2023.1299087. eCollection 2023.

Abstract

To decipher the evolution of the hominoid brain and its functions, it is essential to conduct comparative studies in primates, including our closest living relatives. However, strong ethical concerns preclude in vivo neuroimaging of great apes. We propose a responsible and multidisciplinary alternative approach that links behavior to brain anatomy in non-human primates from diverse ecological backgrounds. The brains of primates observed in the wild or in captivity are extracted and fixed shortly after natural death, and then studied using advanced MRI neuroimaging and histology to reveal macro- and microstructures. By linking detailed neuroanatomy with observed behavior within and across primate species, our approach provides new perspectives on brain evolution. Combined with endocranial brain imprints extracted from computed tomographic scans of the skulls these data provide a framework for decoding evolutionary changes in hominin fossils. This approach is poised to become a key resource for investigating the evolution and functional differentiation of hominoid brains.

Keywords: behavior; histology; hominoid fossil; non-human primates; structural MRI.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Max Planck Society under the inter-institutional funds of the president of the Max Planck Society for the Hominoid Brain Connectomics (now Evolution of Brain Connectivity: EBC) Project. NW has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement No 616905; from the European Union’s Horizon 2020 Research and Innovation Programme under the grant agreement no. 681094; from the BMBF (01EW1711A&B) in the framework of ERA-NET NEURON. NW has received funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—project no. 347592254 (WE 5046/4–2 and KI 1337/2–2). This project has received funding from the Federal Ministry of Education and Research (BMBF) under support code 01ED2210.