A comprehensive review of the ten main platelet receptors involved in platelet activity and cardiovascular disease

Mehrnoosh Hashemzadeh; Fathima Haseefa; Lee Peyton; Mehrdad Shadmehr; Abdullah M Niyas; Aamir Patel; Ghena Krdi; Mohammad Reza Movahed

doi:10.62347/NHUV4765

A comprehensive review of the ten main platelet receptors involved in platelet activity and cardiovascular disease

Am J Blood Res. 2023 Dec 25;13(6):168-188. doi: 10.62347/NHUV4765. eCollection 2023.

Authors

Mehrnoosh Hashemzadeh^{1

2}, Fathima Haseefa¹, Lee Peyton^{2

3}, Mehrdad Shadmehr⁴, Abdullah M Niyas¹, Aamir Patel¹, Ghena Krdi¹, Mohammad Reza Movahed^{1

4}

Affiliations

¹ University of Arizona College of Medicine Phoenix, AZ, USA.
² Pima College Tucson, AZ, USA.
³ Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science Rochester, MN, USA.
⁴ University of Arizona Tucson, AZ, USA.

Abstract

Cardiovascular disease (CVD) is a major cause of death worldwide. Although there are many variables that contribute to the development of this disease, it is predominantly the activity of platelets that provides the mechanisms by which this disease prevails. While there are numerous platelet receptors expressed on the surface of platelets, it is largely the consensus that there are 10 main platelet receptors that contribute to a majority of platelet function. Understanding these key platelet receptors is vitally important for patients suffering from myocardial infarction, CVD, and many other diseases that arise due to overactivation or mutations of these receptors. The goal of this manuscript is to review the main platelet receptors that contribute most to platelet activity.

Keywords: Cardiovascular disease; GPIIb/IIIa; GPIb-IX-V; GPVI; P2X1; P2Y1; P2Y12; PAR1; PAR4; TXA2; platelet receptors; α2β1.

Publication types

Review