Outcome of combined cataract surgery and iris prosthesis implantation in iris melanoma patients previously treated with iridocyclectomy: A national retrospective non-comparative case series

Acta Ophthalmol. 2024 Aug;102(5):581-589. doi: 10.1111/aos.16610. Epub 2024 Jan 13.

Abstract

Purpose: To examine complications, visual outcomes, photic patient-reported symptoms, corneal morphology, IOL tilt, and intraocular pressure after implantation of an intraocular lens (IOL) and iris prosthesis (IP) following iridocyclectomy.

Methods: Patients with previous iridocyclectomy treated with an IOL and IP at the Copenhagen University Hospital Rigshospitalet between 2007 and 2018 were included in this national retrospective non-comparative case series. The assessment encompassed BCVA, PRO questionnaire, corneal topography, and anterior segment OCT.

Results: 45 patients were included. Eight of 45 patients were previously treated with ruthenium-106 brachytherapy in conjunction with iridocyclectomy. Six of 45 patients developed endothelial dysfunction four of whom had received ruthenium-106 brachytherapy. Five of 45 patients had subluxation of the IOL/IP complex due to incomplete zonula apparatus. BCVA improved for all patients after lens surgery. 26 patients participated in the invited follow-up examination. 19 of 26 (73%) reported none or mild photic symptoms after IP instalment. Five (19%) reported ongoing severe photic symptoms. The corneal astigmatism significantly increased after iridocyclectomy but did not change after lens surgery.

Conclusions: Implantation of an IOL and IP is a safe procedure, alleviating photic symptoms in most patients. It comes with higher risk of complications due to a more demanding procedure and larger surgical traumas from previous treatments. Ruthenium-106 brachytherapy increases the complication risk. Corneal astigmatism is induced by iridocyclectomy but does not change after lens surgery.

Keywords: brachytherapy; iridocyclectomy; iris melanoma; iris prosthesis; photophobia; refractive surgery; rehabilitation.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brachytherapy / adverse effects
  • Brachytherapy / methods
  • Cataract Extraction
  • Ciliary Body / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Iridectomy* / methods
  • Iris Neoplasms* / diagnosis
  • Iris Neoplasms* / surgery
  • Iris* / surgery
  • Lens Implantation, Intraocular / methods
  • Male
  • Melanoma* / diagnosis
  • Melanoma* / radiotherapy
  • Melanoma* / surgery
  • Middle Aged
  • Prosthesis Implantation / methods
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Treatment Outcome
  • Visual Acuity*