Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture

J Mol Cell Biol. 2024 Jul 1;16(1):mjae002. doi: 10.1093/jmcb/mjae002.

Authors

Yang Li¹, Qiang Sun^{1

2}, Zhi Yang³, Gang Yuan³

Affiliations

¹ International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China.
² Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China.
³ Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.

No abstract available

Keywords: CRISPR–CasRx; chemically induced dimerization; m6A; mRNA; split-Cas13.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine* / analogs & derivatives
Adenosine* / metabolism
CRISPR-Cas Systems / genetics
Gene Editing / methods
HEK293 Cells
Humans
RNA / genetics
RNA / metabolism
RNA Editing / genetics

Substances

Adenosine
N-methyladenosine
RNA