Diversity-Orientated Synthesis and Biological Properties of Compounds Based on the N-Phenylquinoneimine Scaffold

Adebimpe Adesina; Rachid Skouta

doi:10.3390/molecules29010249

Diversity-Orientated Synthesis and Biological Properties of Compounds Based on the N-Phenylquinoneimine Scaffold

Molecules. 2024 Jan 3;29(1):249. doi: 10.3390/molecules29010249.

Authors

Adebimpe Adesina¹, Rachid Skouta^{2

3}

Affiliations

¹ Department of Chemistry, Federal University of Agriculture, Abeokuta 111101, Nigeria.
² Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
³ Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

Abstract

The N-phenylquinoneimine scaffold is a versatile synthetic platform that has gained significant attention in the field of drug discovery due to its structural diversity and capacity to interact with biologically relevant targets. This review explores established synthetic methodologies and highlights the significant biological activities exhibited by compounds derived from this scaffold, their implications for medicinal chemistry, and the development of novel therapeutics.

Keywords: DNA; N-phenylquinoneimine; biological activity; diversity-orientated synthesis; drugs; reactive metabolites.

Publication types

Review

MeSH terms

Chemistry, Pharmaceutical*
Drug Discovery*

Grants and funding

This research received no external funding.