Single-cell RNA sequencing reveals SERPINE1-expressing CAFs remodelling tumour microenvironment in recurrent osteosarcoma

Clin Transl Med. 2024 Jan;14(1):e1527. doi: 10.1002/ctm2.1527.

Authors

Xin Huang¹, Lutong Wang¹, Haoyu Guo¹, Weiyue Zhang²

Affiliations

¹ Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Bone Neoplasms* / genetics
Humans
Neoplasm Recurrence, Local / genetics
Osteosarcoma* / genetics
Plasminogen Activator Inhibitor 1 / genetics
Sequence Analysis, RNA
Tumor Microenvironment / genetics

Substances

SERPINE1 protein, human
Plasminogen Activator Inhibitor 1

Grants and funding