Refractory cytomegalovirus infections in Chinese patients receiving allogeneic hematopoietic cell transplantation: a review of the literature

Donglin Yang; Yuanyuan Yao; Yi Sun; Erlie Jiang

doi:10.3389/fimmu.2023.1287456

Refractory cytomegalovirus infections in Chinese patients receiving allogeneic hematopoietic cell transplantation: a review of the literature

Front Immunol. 2023 Dec 22:14:1287456. doi: 10.3389/fimmu.2023.1287456. eCollection 2023.

Authors

Donglin Yang^{1

2}, Yuanyuan Yao³, Yi Sun³, Erlie Jiang^{1

2}

Affiliations

¹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
² Tianjin Institutes of Health Science, Tianjin, China.
³ MRL Global Medical Affairs, Shanghai, China.

Abstract

In the absence of prophylactic therapy, cytomegalovirus (CMV) viremia is a common complication following allogeneic hematopoietic cell transplantation (allo-HCT) and represents a significant cause of morbidity and mortality. Approximately 25% of allo-HCT happen in China, where the development and refinement of the 'Beijing protocol' has enabled frequent and increasing use of haploidentical donors. However, refractory CMV infection (an increase by >1 log₁₀ in blood or serum CMV DNA levels after at least 2 weeks of an appropriately dosed anti-CMV medication) is more common among patients with haploidentical donors than with other donor types and has no established standard of care. Here, we review the literature regarding refractory CMV infection following allo-HCT in China.

Keywords: China; allogeneic hematopoietic cell transplantation; cytomegalovirus; haploidentical; refractory.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

China
Cytomegalovirus Infections* / etiology
East Asian People
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Viremia

Supplementary concepts

Chinese people

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This review was funded and sponsored by MSD China. This work was supported by grants from the National Nature Science Foundation of China (No. 82070192 and No. 81670171 to EJ), Haihe Laboratory of Cell Ecosystem Innovation Fund (No. HH22KYZX0034 to EJ), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019XK320076 to DY).