Acute exacerbation of idiopathic pulmonary fibrosis after bivalent {tozinameran and famtozinameran} mRNA COVID-19 vaccination

Kenji Tsumura; Yoshiaki Zaizen; Shushi Umemoto; Shingo Tsuneyoshi; Goushi Matama; Masaki Okamoto; Masaki Tominaga; Tomoaki Hoshino

doi:10.1016/j.rmcr.2023.101960

Acute exacerbation of idiopathic pulmonary fibrosis after bivalent {tozinameran and famtozinameran} mRNA COVID-19 vaccination

Respir Med Case Rep. 2023 Dec 9:46:101960. doi: 10.1016/j.rmcr.2023.101960. eCollection 2023.

Authors

Kenji Tsumura¹, Yoshiaki Zaizen^{1

2}, Shushi Umemoto¹, Shingo Tsuneyoshi¹, Goushi Matama¹, Masaki Okamoto^{1

3}, Masaki Tominaga^{1

4}, Tomoaki Hoshino¹

Affiliations

¹ Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
² Department of Pathology Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
³ Department of Respirology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyouhama, Chuo-ku, Fukuoka 810-8563, Japan.
⁴ Department of Community Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Abstract

An 82-year-old man diagnosed with interstitial lung disease through computed tomography (CT) 1 year prior received a bivalent (tozinameran and famtozinameran) mRNA COVID-19 vaccine. He developed respiratory symptoms 1.5 months later, and chest high-resolution CT revealed new ground-glass opacities showing traction bronchiectasis. Transbronchial lung cryobiopsy revealed organizing acute lung injury and fibrosis with architectural destruction. The patient was diagnosed with an acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). The bivalent mRNA COVID-19 vaccination was determined as the cause of the AE-IPF based on detailed medical history and examination findings. High-dose corticosteroid therapy improved the patient's symptoms and radiological findings.

Keywords: Acute exacerbation; COVID-19 vaccine; Famtozinameran; Idiopathic interstitial pneumonia; Tozinameran.

Publication types

Case Reports