[Relationship between the chemical structure and anticonvulsant activity of 3-hydroxypyridine derivatives]

Farmakol Toksikol. 1986 Nov-Dec;49(6):27-31.
[Article in Russian]

Abstract

It was revealed in experiments on mice, that 3-hydroxypyridine derivatives possess marked anticonvulsive activity, especially in convulsions induced by GABA-ergic substances, less in corasol, maximal electroshock and strychnine induced ones. The anticonvulsive activity in the rows of 2-substituted and 2.6-disubstituted derivatives of 3-hydroxypyridine gets increased due to the introduction of larger in volume alkyl substitutes into the 2nd molecule position. Among the 2,6-disubstituted 3-hydroxypyridine derivatives, agents were revealed that are able to enhance hyperkinesis induced by 5-hydroxytryptophan.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology*
  • Anticonvulsants / therapeutic use
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Electroshock
  • Male
  • Mice
  • Pentylenetetrazole / antagonists & inhibitors
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use
  • Seizures / chemically induced
  • Seizures / drug therapy
  • Structure-Activity Relationship

Substances

  • Anticonvulsants
  • Pyridines
  • 3-hydroxypyridine
  • Pentylenetetrazole