[Diagnosis and evaluation of metabolic dysfunction associated steatotic liver disease (MASLD)]

Abstract

Non-alcoholic fatty liver disease (NAFLD) or recently called Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), is the leading cause of liver disease, with an estimated worldwide prevalence of 25%. MASLD is suspected, in a metabolic condition, in the presence of hepatic steatosis, moderate hepatic cytolysis or hyperferritinemia. The severity of the disease depends on the stage of liver fibrosis, which can be suspected in clinical practice by simple blood tests such as the FIB-4 or NAFLD fibrosis Score. The treatment is based on lifestyle intervention combining weight loss, increased physical activity and a Mediterranean-style diet. Only a small minority of patients with MASLD will develop advanced liver disease and require liver specialist. Given the high prevalence of MASLD, the identification of these patients cannot be envisaged without the taking part in the screening of all physicians (general practitioners and specialists).

Keywords: Cirrhose; Cirrhosis; Fibrose hhépatique; Liver fibrosis; MASLD; Metabolic syndrome; NAFLD; Non-invasive liver fibrosis test; Syndrome métabolique; Test non invasif de fibrose hépatique.