Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation

Jessa E Miller; Jennifer L Taylor-Cousar; Stephen M Humphries; Aastha Khatiwada; Haidee Chen; Alexandra Wilson; Eszter K Vladar; David A Lynch; Douglas A Li; Daniel M Beswick

doi:10.1002/alr.23299

Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation

Int Forum Allergy Rhinol. 2024 May;14(5):986-989. doi: 10.1002/alr.23299. Epub 2023 Dec 26.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, USA.
² Departments of Medicine and Pediatrics, National Jewish Health, Denver, Colorado, USA.
³ Department of Radiology, National Jewish Health, Denver, Colorado, USA.
⁴ Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, Colorado, USA.
⁵ David Geffen School of Medicine, University of California, Los Angeles, California, USA.
⁶ Department of Clinical Research Services, National Jewish Health, Denver, Colorado, USA.
⁷ Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁸ Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁹ Division of Pediatric Pulmonology, University of California, Los Angeles, California, USA.

PMID: 38146638
DOI: 10.1002/alr.23299

Abstract

Individual sinus opacification (ISO) is measurable via a convolutional neural network approach. ISO decreased through 2 years after highly effective modulator therapy was initiated. In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.

Keywords: chronic rhinosinusitis; cystic fibrosis; elexacaftor/tezacaftor/ivacaftor; sinus opacification.

MeSH terms

Adult
Chronic Disease
Cystic Fibrosis* / drug therapy
Female
Humans
Male
Middle Aged
Olfaction Disorders / etiology
Paranasal Sinuses
Quality of Life
Rhinosinusitis*
Smell* / physiology

Abstract

MeSH terms

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