Tuberculosis treatment spills the beans on Wilson's disease and more

Vikram S Kumar; S R Dhananjaya; Shivaraj Gowda

doi:10.1016/j.mjafi.2021.08.018

Tuberculosis treatment spills the beans on Wilson's disease and more

Med J Armed Forces India. 2023 Dec;79(Suppl 1):S276-S279. doi: 10.1016/j.mjafi.2021.08.018. Epub 2021 Oct 29.

Authors

Vikram S Kumar¹, S R Dhananjaya², Shivaraj Gowda¹

Affiliations

¹ Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India.
² Sarji Hospital, Shivamogga, Karnataka, India.

Abstract

Drug-induced liver injury (DILI) is an unwarranted problem and has been a scourge in the treatment of tuberculosis (TB) infection in general and children in particular. Usually, when the Antituberculosis treatment (ATT) regime is temporarily interrupted and modified, DILI subsides, and the whole treatment can be completed under supervision. We report a case of ATT-induced DILI not improving despite modification in the ATT regime, which ultimately led to the revealing of a yet unreported constellation of syndromes that included Wilson Disease, 46 XX gonadal dysgenesis, and Mayer Rokitansky Kuster Hauser (MRKH) Syndrome.

Keywords: Drug-induced liver injury; Tuberculosis; Wilson's disease.

Publication types

Case Reports