MEFV variants are a predisposing factor for generalized pustular psoriasis

Takenori Yoshikawa; Takuya Takeichi; Kazuki Nishida; Yumiko Kobayashi; Hozumi Sano; Akitaka Shibata; Haruka Koizumi; Reiko Tsutsumi; Ryo Fukaura; Masahiro Hayashi; Akiko Imanishi; Kenta Nakamura; Yasutomo Mikoshiba; Eisaku Ogawa; Shinya Sano; Manao Kinoshita; Takashi Okamoto; Reiko Kageyama; Yuko Sano; Sakae Kaneko; Jun Aoi; Toshihide Hara; Yaei Togawa; Mari Kishibe; Yuichi Yoshida; Hiroaki Yagi; Tetsuya Honda; Kazumitsu Sugiura; Shigetoshi Sano; Tamio Suzuki; Tomoo Ogi; Yoshinao Muro; Masashi Akiyama

doi:10.1016/j.jaad.2023.10.070

MEFV variants are a predisposing factor for generalized pustular psoriasis

J Am Acad Dermatol. 2024 Apr;90(4):852-854. doi: 10.1016/j.jaad.2023.10.070. Epub 2023 Dec 19.

Authors

Takenori Yoshikawa¹, Takuya Takeichi², Kazuki Nishida³, Yumiko Kobayashi³, Hozumi Sano⁴, Akitaka Shibata⁵, Haruka Koizumi¹, Reiko Tsutsumi⁶, Ryo Fukaura¹, Masahiro Hayashi⁷, Akiko Imanishi⁸, Kenta Nakamura⁹, Yasutomo Mikoshiba⁹, Eisaku Ogawa⁹, Shinya Sano¹⁰, Manao Kinoshita¹⁰, Takashi Okamoto¹⁰, Reiko Kageyama¹¹, Yuko Sano¹², Sakae Kaneko¹³, Jun Aoi¹⁴, Toshihide Hara¹⁵, Yaei Togawa¹⁶, Mari Kishibe¹⁷, Yuichi Yoshida⁶, Hiroaki Yagi¹², Tetsuya Honda¹¹, Kazumitsu Sugiura¹⁸, Shigetoshi Sano⁴, Tamio Suzuki⁷, Tomoo Ogi¹⁹, Yoshinao Muro¹, Masashi Akiyama²⁰

Affiliations

¹ Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
² Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: takeichi@med.nagoya-u.ac.jp.
³ Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
⁴ Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan.
⁵ Department of Dermatology, Prefectural Tajimi Hospital, Tajimi, Japan.
⁶ Division of Dermatology, Department of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.
⁷ Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
⁸ Department of Dermatology, Osaka City General Hospital, Osaka, Japan.
⁹ Department of Dermatology, Shinshu University, Nagano, Japan.
¹⁰ Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
¹¹ Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
¹² Department of Dermatology, Shizuoka General Hospital, Shizuoka, Japan.
¹³ Department of Dermatology, Masuda Red Cross Hospital, Shimane, Japan.
¹⁴ Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
¹⁵ Department of Dermatology, Japan Community Health care Organization, Isahaya General Hospital, Isahaya, Japan.
¹⁶ Department of Dermatology, Chiba University Hospital, Chiba, Japan.
¹⁷ Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
¹⁸ Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
¹⁹ Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
²⁰ Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: makiyama@med.nagoya-u.ac.jp.

PMID: 38128830
DOI: 10.1016/j.jaad.2023.10.070

No abstract available

Keywords: Mediterranean fever; familial Mediterranean fever; generalized pustular psoriasis; pustular skin disease.

Publication types

Letter

MeSH terms

Acute Disease
Causality
Chronic Disease
Humans
Psoriasis* / epidemiology
Psoriasis* / genetics
Pyrin / genetics

Substances

MEFV protein, human
Pyrin