Aflatoxin B1 and viruses' combined pathogenesis: A mini systematics review of invitro and invivo studies

Mehdi Ahmadi; Ramin Shahbahrami; Fatemeh Khajeh; Sepideh Khodaeivandi; Ehsan Kakavandi; Reza Hazrati Raziabad; Kiandokht Ghanati

doi:10.1016/j.acthis.2023.152116

Aflatoxin B1 and viruses' combined pathogenesis: A mini systematics review of invitro and invivo studies

Acta Histochem. 2024 Jan;126(1):152116. doi: 10.1016/j.acthis.2023.152116. Epub 2023 Dec 14.

Authors

Mehdi Ahmadi¹, Ramin Shahbahrami², Fatemeh Khajeh³, Sepideh Khodaeivandi⁴, Ehsan Kakavandi⁵, Reza Hazrati Raziabad¹, Kiandokht Ghanati⁶

Affiliations

¹ Student Research Committee, (Department and Faculty of Nutrition Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Department of Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
³ Department of Environmental Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
⁴ Department of Food Science and Technology, Afagh Higher Education institute, Urmia, Iran.
⁵ Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Student Research Committee, (Department and Faculty of Nutrition Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: k.ghanati@sbmu.ac.ir.

PMID: 38101290
DOI: 10.1016/j.acthis.2023.152116

Abstract

Introduction: The combined pathogenesis of Aflatoxin B1 (AFB1) and several viruses such as HBV, EBV and influenza virus have been investigated yet the molecular mechanism of their interaction and possible synergistic effects is not fully understood.

Objectives: The aim of the current systematic review was to review in-vitro and in-vivo studies investigating the combined pathogenesis of aflatoxins and viruses.

Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. PECO (Population, Exposure, Comparator, and Outcome) criteria for invitro and invivo studies were used to evaluate the eligibility of the studies for systematic review.

Results: 21 studies were eligible for qualitative analysis based on the inclusion criteria. Of all the included studies, 9 (42.9 %) were invivo, 7 (33.3 %) were invitro-invivo and 5(23.8) articles conducted only invitro assay. Furthermore 14 (66.6 %) article explored hepatitis B virus (HBV) combination with AFB1, 4 (19 %) studied influenza A virus (SIV), 2 (9.7 %) were about Epstein-Barr virus (EBV) and only 1 (4.7 %) included hepatitis C virus (HCV).

Conclusion: The limited collected evidence suggests that AFB1 enhanced EBV and influenza virus pathogenesis. AFB1 also operated as a cofactor for HBV and EBV-mediated carcinogenesis. On the other hand HBV and HCV also induced AFB-1 carcinogenesis. Due to the limited amount of included studies and the inconsistency of their results further studies especially on HBV and SIV are essential for better understanding of their combined mechanisms.

Keywords: Aflatoxins; In-vitro; In-vivo; Systematic review; Viral disease; Viral infection.

Publication types

Systematic Review
Review

MeSH terms

Aflatoxin B1* / toxicity
Animals
Hepatitis B / virology
Hepatitis B virus* / pathogenicity
Herpesvirus 4, Human / pathogenicity
Humans
Influenza A virus / pathogenicity

Substances

Aflatoxin B1