Glatiramer acetate induces mast cell degranulation via MRGPRX2, implications for local and systemic adverse reactions

Allergy. 2024 Mar;79(3):758-761. doi: 10.1111/all.15978. Epub 2023 Dec 14.

Authors

Shaswati Chaki¹, Aetas Amponnawarat^{1

2}, Brett Levenstein¹, Yvonne Hui³, Carole Oskeritzian³, Hydar Ali¹

Affiliations

¹ Department of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.
² Department of Family and Community Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
³ Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South California, USA.

PMID: 38095027
PMCID: PMC10922971 (available on 2025-03-01)
DOI: 10.1111/all.15978

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Anaphylaxis*
Cell Degranulation
Drug Hypersensitivity*
Glatiramer Acetate
Humans
Mast Cells
Nerve Tissue Proteins
Receptors, G-Protein-Coupled
Receptors, Neuropeptide

Substances

Glatiramer Acetate
Receptors, G-Protein-Coupled
MRGPRX2 protein, human
Nerve Tissue Proteins
Receptors, Neuropeptide

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